diff --git a/lib/crewai/src/crewai/agent/core.py b/lib/crewai/src/crewai/agent/core.py
index 54ae52ba8..1d94c4d19 100644
--- a/lib/crewai/src/crewai/agent/core.py
+++ b/lib/crewai/src/crewai/agent/core.py
@@ -860,19 +860,29 @@ class Agent(BaseAgent):
 
         try:
             try:
-                tools_list = asyncio.run(_setup_client_and_list_tools())
-            except RuntimeError as e:
-                error_msg = str(e).lower()
-                if "cancel scope" in error_msg or "task" in error_msg:
+                asyncio.get_running_loop()
+                import concurrent.futures
+
+                with concurrent.futures.ThreadPoolExecutor() as executor:
+                    future = executor.submit(
+                        asyncio.run, _setup_client_and_list_tools()
+                    )
+                    tools_list = future.result()
+            except RuntimeError:
+                try:
+                    tools_list = asyncio.run(_setup_client_and_list_tools())
+                except RuntimeError as e:
+                    error_msg = str(e).lower()
+                    if "cancel scope" in error_msg or "task" in error_msg:
+                        raise ConnectionError(
+                            "MCP connection failed due to event loop cleanup issues. "
+                            "This may be due to authentication errors or server unavailability."
+                        ) from e
+                except asyncio.CancelledError as e:
                     raise ConnectionError(
-                        "MCP connection failed due to event loop cleanup issues. "
-                        "This may be due to authentication errors or server unavailability."
+                        "MCP connection was cancelled. This may indicate an authentication "
+                        "error or server unavailability."
                     ) from e
-            except asyncio.CancelledError as e:
-                raise ConnectionError(
-                    "MCP connection was cancelled. This may indicate an authentication "
-                    "error or server unavailability."
-                ) from e
 
             if mcp_config.tool_filter:
                 filtered_tools = []
diff --git a/lib/crewai/src/crewai/tools/mcp_native_tool.py b/lib/crewai/src/crewai/tools/mcp_native_tool.py
index c10d51eee..f25b2f4d7 100644
--- a/lib/crewai/src/crewai/tools/mcp_native_tool.py
+++ b/lib/crewai/src/crewai/tools/mcp_native_tool.py
@@ -86,9 +86,17 @@ class MCPNativeTool(BaseTool):
             Result from the MCP tool execution.
         """
         try:
-            # Always use asyncio.run() to create a fresh event loop
-            # This ensures the async context managers work correctly
-            return asyncio.run(self._run_async(**kwargs))
+            try:
+                asyncio.get_running_loop()
+
+                import concurrent.futures
+
+                with concurrent.futures.ThreadPoolExecutor() as executor:
+                    coro = self._run_async(**kwargs)
+                    future = executor.submit(asyncio.run, coro)
+                    return future.result()
+            except RuntimeError:
+                return asyncio.run(self._run_async(**kwargs))
 
         except Exception as e:
             raise RuntimeError(
diff --git a/lib/crewai/tests/mcp/test_mcp_config.py b/lib/crewai/tests/mcp/test_mcp_config.py
index 627ceb6e2..e55a7d504 100644
--- a/lib/crewai/tests/mcp/test_mcp_config.py
+++ b/lib/crewai/tests/mcp/test_mcp_config.py
@@ -1,4 +1,5 @@
-from unittest.mock import AsyncMock, patch
+import asyncio
+from unittest.mock import AsyncMock, MagicMock, patch
 
 import pytest
 from crewai.agent.core import Agent
@@ -134,3 +135,66 @@ def test_agent_with_sse_mcp_config(mock_tool_definitions):
         transport = call_args.kwargs["transport"]
         assert transport.url == "https://api.example.com/mcp/sse"
         assert transport.headers == {"Authorization": "Bearer test_token"}
+
+
+def test_mcp_tool_execution_in_sync_context(mock_tool_definitions):
+    """Test MCPNativeTool execution in synchronous context (normal crew execution)."""
+    http_config = MCPServerHTTP(url="https://api.example.com/mcp")
+
+    with patch("crewai.agent.core.MCPClient") as mock_client_class:
+        mock_client = AsyncMock()
+        mock_client.list_tools = AsyncMock(return_value=mock_tool_definitions)
+        mock_client.connected = False
+        mock_client.connect = AsyncMock()
+        mock_client.disconnect = AsyncMock()
+        mock_client.call_tool = AsyncMock(return_value="test result")
+        mock_client_class.return_value = mock_client
+
+        agent = Agent(
+            role="Test Agent",
+            goal="Test goal",
+            backstory="Test backstory",
+            mcps=[http_config],
+        )
+
+        tools = agent.get_mcp_tools([http_config])
+        assert len(tools) == 2
+
+
+        tool = tools[0]
+        result = tool.run(query="test query")
+
+        assert result == "test result"
+        mock_client.call_tool.assert_called()
+
+
+@pytest.mark.asyncio
+async def test_mcp_tool_execution_in_async_context(mock_tool_definitions):
+    """Test MCPNativeTool execution in async context (e.g., from a Flow)."""
+    http_config = MCPServerHTTP(url="https://api.example.com/mcp")
+
+    with patch("crewai.agent.core.MCPClient") as mock_client_class:
+        mock_client = AsyncMock()
+        mock_client.list_tools = AsyncMock(return_value=mock_tool_definitions)
+        mock_client.connected = False
+        mock_client.connect = AsyncMock()
+        mock_client.disconnect = AsyncMock()
+        mock_client.call_tool = AsyncMock(return_value="test result")
+        mock_client_class.return_value = mock_client
+
+        agent = Agent(
+            role="Test Agent",
+            goal="Test goal",
+            backstory="Test backstory",
+            mcps=[http_config],
+        )
+
+        tools = agent.get_mcp_tools([http_config])
+        assert len(tools) == 2
+
+
+        tool = tools[0]
+        result = tool.run(query="test query")
+
+        assert result == "test result"
+        mock_client.call_tool.assert_called()